منابع مشابه
Adverse effects of glucocorticoids: coagulopathy.
Hypercortisolism is associated with various systemic manifestations, including central obesity, arterial hypertension, glucose intolerance/diabetes mellitus, dyslipidemia, nephrolithiasis, osteoporosis, gonadal dysfunction, susceptibility to infections, psychiatric disorders, and hypercoagulability. The activation of the hemostatic system contributes to the development of atherosclerosis and su...
متن کاملGlucocorticoids antagonize tumor necrosis factor-α-stimulated lipolysis and resistance to the antilipolytic effect of insulin in human adipocytes.
High concentrations of TNF within obese adipose tissue increase basal lipolysis and antagonize insulin signaling. Adipocytes of the obese are also exposed to elevated levels of glucocorticoids (GCs), which antagonize TNF actions in many cell types. We tested the hypothesis that TNF decreases sensitivity to the antilipolytic effect of insulin and that GCs antagonize this effect in differentiated...
متن کاملPost-transcriptional and nongenomic effects of glucocorticoids.
The ability of glucocorticoids to interfere with post-transcriptional gene regulation has recently been recognized as a potentially important part of their anti-inflammatory property, and the mechanisms governing such activity are under active investigation. Several studies have shown that glucocorticoids can inhibit inflammatory signaling pathways known to control mRNA turnover and translation...
متن کاملMajor Side-effects of Glucocorticoids in Japan.
The present statistical investigation was undertaken in order to establish what is the most significant out of various side-effects of glucocorticoids(GC) in Japan. From the viewpoint of mortality, side-effects of GC can be classified into two groups:"Major" and"Minor" side-effects."Minor side-effects" denotes moonface, obesity, hypertrichosis, anorexia, polyphagia, headache, hypertension, hype...
متن کاملAdverse skeletal effects of drugs - beyond Glucocorticoids.
Osteoporotic fractures are an important public health problem with significant individual and societal costs. In addition to the major risk factors for osteoporotic fracture, low bone mineral density (BMD), age, low body weight and history of fracture or falls, some drugs are now considered to be important secondary risk factor for bone loss and fracture, particularly amongst predisposed indivi...
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ژورنال
عنوان ژورنال: The FASEB Journal
سال: 2011
ISSN: 0892-6638,1530-6860
DOI: 10.1096/fasebj.25.1_supplement.1103.3